Studies on 1-Alkyl-2(1<i>H</i>)-pyridone Derivatives. IV

Studies on alkyl-xanthine derivatives. II. Pharmacokinetic and pharmacodynamic studies of a new bronchodilator, 1-methyl-3-propylxanthine (MPX).

A new xanthine derivative bronchodilator, 1-methyl-3-propylxanthine (MPX), and 1-methyl-3-butylxanthine (MBX) were synthesized. We evaluated their relaxant effects on tracheal smooth muscle isolated from guinea pigs and pharmacokinetic characteristics in rats using 1,3-dimethylxanthine (theophylline, TPH) as the reference drug. Dose-dependent relaxant effects were observed in the concentration ...

Pharmacological studies and synthesis of morpholino alkyl derivatives.

Seven morpholin derivatives were synthesized (compounds 1-7) and their behavioural effects were evaluated; the elements considered were locomotor activity, motor coordination, catalepsy, stereotyped behaviour and antinociception. All the compounds, at doses of 10-20-40 mg/kg/i.p., induced a reduction of all behavioural elements without a significant antinociceptive effect. These results indicat...

Isoquinoline Promoted Synthesis of alkyl 2-(1-alkyl-5-oxo-3-phenyl-2-thioxotetrahydro-4H-imidazol-4-yliden) acetate derivatives

Derivatives of thiazolidinone ring systems are known to act as anti-HIV infections , analgesic, anti-bacterial, anti-convulsant, anti parasitic, potential anti-inflammatory and herbicidal agents. Due biological activities of thiazolidinones ring, several methods for their synthesis have been illustrated in literature. Imidazolidine-2-thiones were synthesized by the oxidative cyclization of 1-be...

Effect of 1-alkyl- or 1-alkenylazacycloalkanone derivatives on penetration of mitomycin C through rat skin.

(3, 7, 11-trimethyldodecyl ) azacycloheptan-2-one (7FS), l-geranylgeranylazacycloheptan-2-one (7GGU), and 1-geranylgeranylazacyclohexan-2-one (6GGU), on percutaneous penetration of mitomycin C (MMC) through rat skin in vitro were investigated in comparison with those of 1farnesylazacycloheptan-2-one (7FU) and 1-dodecylazacycloheptan-2-one (Azone) . In an in vitro diffusion experiment, 6GU, 7GS,...

Studies on nicotinamide derivatives.